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International Maternal Pediatric Adolescent AIDS Clinical Trials Group Opportunistic Infections Subcommittee of Complications of HIV RAC Goals and Objectives |
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International Maternal Pediatric Adolescent AIDS Clinical Trials Group Opportunistic Infections Subcommittee of Complications of HIV RAC Goals and Objectives |
The Opportunistic Infections Subcommittee members must have special knowledge of diverse opportunistic infectious agents (bacteria, viruses, fungi), immunopathogenesis (particularly cellular immunity), and pharmacology (first- and second-line antimicrobials) to deal with those infections that cause morbidity and mortality in HIV-infected children. Opportunistic infection protocols will be either primary or nested.
Following are the specific aims of the Opportunistic Infections Subcommittee:
| Specific Aim 1. | To determine in children the pharmacokinetic and pharmacodynamic properties of antimicrobial agents for pathogens important in pediatric HIV infection so that rational and optimal use is possible. |
| Specific Aim 2. | To determine pharmacokinetics, drug interaction, safety, and efficacy of a broad-spectrum multiple opportunistic pathogen prophylaxis (MOPP) scheme for HIV-infected children. |
| Specific Aim 3. | To evaluate the immunogenicity, duration of immunity, and safety of childhood vaccines in HIV-infected infants and children in order to optimize their use in this population. |
| Specific Aim 4. | To investigate the pathogenetic interaction between opportunistic infections and the progression of HIV infection in children through the conduct of interventional trials. |
| Specific Aim 5. | To identify and develop new laboratory technologies for opportunistic pathogens that will be useful in the conduct of clinical trials. |
