The mission of the IMPAACT group, which is worldwide in scope, will be to significantly decrease the mortality and morbidity associated with HIV disease in pregnant women, children, and adolescents by:

• Developing and evaluating safe and cost effective approaches for the interruption of mother-to-infant transmission
• Evaluating treatments for HIV-infected children, adolescents, and pregnant women, including treatment and prevention of co-infections and co-morbidities
• Evaluating vaccines for the prevention of HIV sexual transmission among adolescents